摘要
幽门螺杆菌(Helicobacter pylori,Hp)是一种革兰阴性杆菌,被世界卫生组织国际癌症研究机构列为Ⅰ类致癌物,具有传染性.Hp感染后导致宿主胃和其他部位炎症的发生,且不同毒力型幽门螺杆菌感染引起的炎症反应程度不完全一致,反映在不同毒力型幽门螺杆菌感染后产生的各种炎症因子表达存在差异,其机制未完全清楚.本文就近年来国内外对不同Hp毒力因子感染及其引起的炎症因子,如白细胞介素-1β(IL-1β)、IL-2、IL-4、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)的变化进行综述.
Abstract
Helicobacter pylori(Hp)is a kind of Gram-negative bacillus,listed as a groupⅠcarcinogen by the International Agency for Research on Cancer of the World Health Organization,and is contagious.Hp leads to the occurrence of gastric and other parts systemic inflammation of the host,and the degree of inflammatory reaction caused by different virulent Hp infection is not completely consistent,which is reflected in the different expression of various inflammatory factors produced by different virulent Hp,and its mechanism is not completely clear.In recent years,different Hp virulence factor infection and its induced inflammatory factors,such as interleukin-1β(IL-1β),IL-2,IL-4,IL-6,IL-8,tumor necrosis factor-α(TNF-α),gamma-interferon(IFN-γ)were reviewed at home and abroad.
基金项目
右江民族医学院附属医院科研项目(R20212609)
维普
万方数据