Effect of Yixin Granules Combined with Sacubitril Valsartan Sodium in the Treatment of Chronic Heart Failure and Its Influence on Vascular Endothelial Function
Objective:To investigate the effect of Yixin Granules combined with Sacubitril Valsartan Sodium in the treatment of chronic heart failure(CHF).Method:A total of 160 CHF patients who were treated in the Department of Cardiovascular Medicine,Linyi Central Hospital from February 2022 to February 2023 were selected.They were randomly divided into a control group(treated with Sacubitril Valsartan Sodium)and an observation group(treated with Yixin Granules in addition to the control group)using a random number table method,with 80 patients in each group.Cardiac function[left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)],total effective rate of treatment,vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1)],neuroendocrine levels[aldosterone(ALD),plasma renin activity(PRA),angiotensin Ⅱ(AngⅡ)]and the levels of myocardial related factors[soluble growth stimulating gene 2 protein(sST2),heart type fatty acid binding protein(hFABP)and lipoprotein associated phospholipase A2(Lp-PLA2)]of the two groups were compared.Result:Before treatment,there were no significant differences in cardiac function indexes between the two groups(P>0.05).After treatment,LVEF in both groups increased,LVESD and LVEDD decreased,LVEF in observation group was higher than that in control group,LVESD and LVEDD were lower than those in control group,the differences were statistically significant(P<0.05).The treatment total effective rate of control group was lower than that of observation group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in vascular endothelial function indexes between the two groups(P>0.05).After treatment,NO increased and ET-1 decreased in both groups,NO in observation group was higher than that in control group,and ET-1 was lower than that in control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in neuroendocrine levels between the two groups(P>0.05).After treatment,the levels of ALD,PRA and AngⅡ in both groups decreased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in myocardial related factors levels between the two groups(P>0.05).After treatment,the levels of sST2,hFABP and Lp-PLA2 in both groups decreased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Treatment of CHF patients with Yixin Granules combined with Sacubitril Valsartan Sodium can improve cardiac function and vascular endothelial function,and the effect is remarkable.Its mechanism may be related to down-regulating the levels of ALD,PRA,AngⅡ,sST2,hFABP and Lp-PLA2.
Yixin GranulesSacubitril Valsartan SodiumChronic heart failureVascular endothelial functionNeuroendocrineCardiac function
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