Effect of Different Administration Time of Biapenem on the Therapeutic Effect in Patients with Acute Sepsis Complicated with Infectious Shock
Objective:To investigate the effect of different administration time of Biapenem on the therapeutic effect in patients with acute sepsis complicated with infectious shock.Method:A total of 70 patients with acute sepsis complicated with infectious shock admitted to the Department of Infectious Diseases,Jiujiang NO.1 People's Hospital from January 2021 to June 2023 were selected as the study objects and divided into two groups according to treatment methods.The control group(n=30)was treated by routine infusion of Biapenem for 30 min,and the observation group(n=40)was treated by infusion of Biapenem for 2 h.The clinical effects and the occurrence of adverse reactions were compared between the two groups,the health scores of the patients were evaluated before and after treatment,and the blood routine indexes of the patients were measured.Result:The effective rate of observation group(95.00%)was significantly higher than that of control group(73.33%)(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(7.50%)and the control group(13.33%)(P>0.05).After treatment,acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)score and sequential organ failure assessment(SOFA)score in observation group were significantly lower than those in control group(P<0.05).After treatment,the white blood cell count(WBC),neutrophil(N),procalcitonin(PCT),erythrocyte sedimentation rate(ESR)and C reactive protein(CRP)in observation group were significantly lower than those in control group(P<0.05).Conclusion:Compared with the conventional 30 min infusion of Biapenem,the 2-hour extension of infusion for the treatment of acute sepsis complicated with infectious shock can further improve the therapeutic effect,inhibit the inflammatory response,reduce the organ function damage of patients,and improve the health status of patients.Moreover,the extension of administration time will not increase the adverse reactions,and has high safety.
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