Effect of Sacubactril Valsartan on Maintenance Hemodialysis Patients with Ejection Fraction Preserving Heart Failure
Objective:To observe the effect of Sacubactril Valsartan in maintenance hemodialysis patients with heart failure with preserved ejection fraction.Method:The research objects were 60 maintenance hemodialysis patients with ejection fraction preserving heart failure who were admitted to Pingxiang People's Hospital from October 2021 to October 2022.They were randomly divided into treatment group and control group,with 30 cases in each group.The treatment group was given Metoprolol Tartrate + Sacubitril Valsartan Tablets,while the control group was given Metoprolol Tartrate + Losartan Potassium Tablets.The blood calcium,blood phosphorus,N-terminal B-type natriuretic peptide(NT-proBNP),NYHA cardiac function grade,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),adverse reactions and major adverse cardiac events(MACEs)of the two groups were analyzed.Result:After treatment,there were no significant differences in blood phosphorus and calcium levels between the two groups(P>0.05).Compared with those before treatment,the levels of NT-proBNP in the two groups decreased after treatment,and the level in the treatment group was lower,with statistical significance(P<0.05).After treatment,the NYHA cardiac function grade of the treatment group was better than that of the control group,the difference was statistically significant(P<0.05).Compared with those before treatment,LVEDD and LVESD levels decreased in both groups after treatment and those were lower in the treatment group;LVEF levels increased in both groups after treatment and that is higher in the treatment group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of MACEs in treatment group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:Sacubactril Valsartan has a significant effect on the improvement of cardiac function in maintenance hemodialysis patients with ejection fraction preservation heart failure,and has a high safety.
国家科技期刊平台
NSTL
万方数据
