Effects of CVVHDF in Combination with Acetyl Piloside and Meropenem on Inflammatory Factors and Myocardial Injury Indexes in Elderly Patients with Severe Pneumonia Complicated with Heart Failure
Objective:To investigate the effect of continuous veno-venous hemodiafiltration(CVVHDF)in combination with Acetyl Piloside and Meropenem on inflammatory factors and myocardial injury indicators in elderly patients with severe pneumonia and heart failure.Method:From June 2020 to May 2023,82 elderly patients with severe pneumonia and heart failure admitted to Ganzhou Hospital,Guangdong Provincial People's Hospital were selected and analyzed.They were randomly divided into CVVHDF group(treatment with CVVHDF in combination with Acetyl Piloside and Meropenem,n=41)and drug group(treatment with Acetyl Piloside combined with Meropenem,n=41).The ICU stay time,total hospitalization time,cough relief time,lung rale disappearance time,inflammatory factors[serum procalcitonin(PCT),C reactive protein(CRP),interleukin-6(IL-6)levels],myocardial injury indicators[creatine kinase(CK),lactate dehydrogenase(LDH),serum troponin I(cTnI)],blood gas indicators[arterial oxygen saturation(SaO2),arterial carbon dioxide pressure(PaCO2),arterial oxygen pressure(PaO2)levels]and acute physiological and chronic health evaluation Ⅱ(APACHEⅡ)were analyzed and compared between the two groups.Result:The retention time in ICU,total hospitalization time of the CVVHDF group were shorter than those of the drug group,cough relief time and pulmonary rales disappearance time of the CVVHDF group were earlier than those of the drug group(P<0.05).After treatment,the serum PCT,CRP and IL-6 levels in the two groups decreased,compared with the drug group,those in the CVVHDF group were lower(P<0.05).After treatment,the levels of CK,LDH and serum cTnI decreased in both groups,compared with the drug group,those in the CVVHDF group were lower(P<0.05).After treatment,the serum PaCO2 levels and APACHEⅡ scores in both groups decreased,compared with the drug group,those in the CVVHDF group were lower(P<0.05);after treatment,the levels of PaO2 and SaO2 in both groups significantly increased,and compared with the drug group,those in the CVVHDF group were higher(P<0.05).Conclusion:CVVHDF in combination with Acetyl Piloside and Meropenem in the treatment of elderly patients with severe pneumonia and heart failure can significantly improve their myocardial function,improve their ventilatory function,reduce their inflammatory reaction,and accelerate their rehabilitation process.
Elderly severe pneumoniaHeart failureAcetyl PilosideContinuous veno-venous hemodiafiltrationInflammatory factorsMyocardial damage
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