The Effect of Shengwei Powder Combined with Sucralfate on Changes in Gastrointestinal Hormones and Gut Microbiota in Patients with Chronic Gastritis
Objective:To explore the effects of Shengwei Powder combined with Sucralfate on changes in gastrointestinal hormones and gut microbiota in patients with chronic gastritis.Method:A total of 86 patients with chronic gastritis admitted to Department of Gastroenterology,Beihai Hospital of Yantai from June 2022 to April 2023 were selected as the study objects,and were divided into observation group and control group according to computer random table method,with 43 cases in each group.The control group was given oral Sucralfate Suspension,and the observation group was treated with Shengwei Powder based on the control group.The effects,changes of intestinal flora,gastrointestinal hormones and inflammatory status were compared between the two groups.Result:Before treatment,there were no significant differences in gastrin and motilin levels between the two groups(P>0.05);after treatment,the levels of motilin and gastrin in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the count of Bacteroides and Enterobacter were decreased than those before treatment,the count of Bifidobacterium and Lactobacillus were increased in both groups(P<0.05).After treatment,interleukin-8(IL-8),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)were decreased in both groups compared with those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Shengwei Powder combined with Sucralfate in the treatment of chronic gastritis can regulate gastrointestinal hormone and intestinal flora,reduce inflammatory response,with good effect and safety.
国家科技期刊平台
NSTL
万方数据
