Effect of Cathodic Transcranial Direct Current Stimulation on Acute Phase Stroke and Its Influence on Neurological Function
Objective:To investigate the effect of cathodic transcranial direct current stimulation on acute phase stroke and its influence on neurological function.Method:The study was conducted from September 2019 to September 2021.A total of 82 patients with acute phase stroke who received treatment in Rushan People's Hospital during this period were selected and divided into control group(n=41)and observation group(n=41)according to random number table method.The control group received routine rehabilitation training,and the observation group was treated with cathodic transcranial direct current stimulation on the basis of control group.The motor function[Fugl-Meyer assessment(FMA),action research arm test(ARAT)],ability of daily living[modified Barthel index(MBI)],neural function deficient situation and cognitive function[neural function deficient scale(NDS),European stroke scale(ESS)and Montreal cognitive assessment(MoCA)],inflammatory factors[hypersensitive C reactive protein(hs-CRP),superoxide dismutase(SOD),interleukin-10(IL-10),serine protease inhibitor],neuro factors[hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF),brain derived neurotrophic factor(BNDF)]were compared between the two groups.Result:Before treatment,there were no significant differences in FMA,ARAT and MBI scores between the two groups(P>0.05).After treatment,FMA,ARAT and MBI scores of both groups were increased,and those in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in NDS,ESS and MoCA scores between the two groups(P>0.05).After treatment,the NDS scores of both groups were decreased,that in the observation group was lower than that in the control group,the MoCA and ESS scores of both groups were increased,and those in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in the levels of hs-CRP,SOD,IL-10 and serine protease inhibitor between the two groups(P>0.05).After treatment,the levels of hs-CRP and IL-10 in both groups were decreased,those in the observation group were lower than those in the control group,the levels of SOD and serine protease inhibitor in both groups were increased,and those in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in the levels of HIF-1α,VEGF and BNDF between the two groups(P>0.05).After treatment,HIF-1α levels were decreased in both groups,that in the observation group was lower than that in the control group,VEGF and BNDF levels were increased in both groups,and those in the observation group were higher than those in the control group(P<0.05).Conclusion:The patients with acute phase stroke receive cathodic transcranial direct current stimulation can improve the neural function deficient,improve the motor function,reduce the inflammatory response and improve the cognitive ability of the patients.
Cathodic transcranial direct current stimulationAcute phaseStrokeCognitive functionNeural function
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