Effect of Different Durations Mild Hypothermia on Immune Function and Prognosis in Patients with Severe Traumatic Brain Injury
Objective:To analyze and compare the effectiveness of different durations mild hypothermia in the treatment of patients with severe traumatic brain injury(STBI).Method:A total of 120 patients with STBI admitted to First Affiliated Hospital of Gannan Medical College from July 2020 to March 2023 were selected,and divided into three groups by random number table method,with 40 patients in each group.The conventional group received basic treatment of dehydration,intracranial pressure reduction,and decompressive craniectomy,while the control group received short-term(2 d treatment)mild hypothermia treatment,the observation group received long-term(5 d treatment)mild hypothermia treatment on the basis of the conventional group.The severity of the condition,immune function,oxygenation status,occurrence of complications and prognosis among the three groups were compared.Result:Before treatment,acute physiological and chronic health evaluation Ⅱ(APACHEⅡ)scores,CD4+,CD4+/CD8+,interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),central venous oxygen saturation(ScvO2),arterial venous carbon dioxide partial pressure difference[P(cv-a)CO2]of the three groups were cpmpared,the differences were not statistically significant(P>0.05);after treatment,APACHEⅡscore,IL-6,TNF-α,IFN-γ and P(cv-a)CO2 in the observation group were lower than those in the control group and the conventional group,while CD4+,CD4+/CD8+,ScvO2 were higher than those in the control group and the conventional group,the differences were statistically significant(P<0.05).The incidence of complications and 28 d mortality rate in the observation group and control group were lower than those in the conventional group,the differences were statistically significant(P<0.05).There were no statistically significant differences in the incidence of complications and 28 d mortality between the control group and the observation group(P>0.05).Conclusion:Long-term mild hypothermia treatment has a better effect on STBI patients,can effectively control the condition,improve their immune function,and have a lower incidence of complications and 28 d mortality rate,improving patient prognosis.
Severe traumatic brain injuryMild hypothermiaImmune function
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