Effect of Transanal Total Mesorectal Excision on Rectal Cancer and Its Influence on Gastrointestinal Function
Objective:To investigate the effect of transanal total mesorectal excision(taTME)on rectal cancer.Method:A total of 94 patients with rectal cancer treated in Zaozhuang Municipal Hospital from April 2021 to April 2023 were selected and divided into control group[given total mesorectal excision(TME)]and observation group(given taTME)according to random number table method,with 47 cases in each group.Intraoperative clinical indexes,postoperative clinical indexes,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C reactive protein(CRP)],gastrointestinal function[motilin(MOT),gastrin(GAS),basic fibroblast growth factor(BFGF)],anal function[anal maximum squeeze pressure(AMSP),anal resting pressure(ARP),rectal maximal tolerate volume(RMTV)]and the incidence of complications were compared between the two groups.Result:The operation time of the observation group was longer than that of the control group,and the intraoperative bleeding volume was less than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the number of lymph node dissection between the two groups(P>0.05).The time of exhaust,eating,bowel and bowel sound recovery in observation group were earlier than those in control group,the differences were statistically significant(P<0.05).Before operation,there were no significant differences in the levels of inflammatory factors between the two groups(P>0.05);after operation,TNF-α,IL-6 and CRP were decreased in both groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before operation,there were no significant differences in gastrointestinal function indexes between the two groups(P>0.05);after operation,MOT,GAS and BFGF were decreased in both groups,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before operation,there were no significant differences in anal function indexes between the two groups(P>0.05);after operation,AMSP,ARP and RMTV were decreased in both groups,but those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Patients with rectal cancer choose laparoscopy combined with taTME can reduce inflammatory reaction,have little influence on anal function and gastrointestinal function,and reduce the incidence of complications.
Transanal total mesorectal excisionRectal cancerGastrointestinal function
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