Effect of Imipenem and Cilastatin Sodium Combined with Ulinastatin and Continuous Hemofiltration in the Treatment of Severe Pancreatitis with Septic Shock
Objective:To analyze the effects of Imipenem and Cilastatin Sodium combined with Ulinastatin and continuous hemofiltration on the myocardial enzyme spectrum of severe pancreatitis with septic shock.Method:A total of 96 patients with severe pancreatitis and septic shock admitted to the ICU of Xiamen Third Hospital from January 1,2017 to June 30,2022 were selected,they were randomly divided into a study group(48 cases)and a control group(48 cases)using a random number table method.The control group was treated with Ulinastatin and continuous hemofiltration,while the study group was treated with Imipenem and Cilastatin Sodium in addition to the control group.The clinical efficacy of the two groups was compared.Result:The rescue success rate,transforming growth factor-β(TGF-β)and mean arterial pressure(MAP)of the study group were higher than those of the control group,the levels of amylase(AMS),alanine aminotransferase(ALT),creatine kinase isoenzyme(CK-MB),creatine kinase(CK),procalcitonin(PCT),C reactive protein(CRP)and white blood cell count(WBC)were lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:Imipenem and Cilastatin Sodium combined with Ulinastatin and continuous hemofiltration are effective in the treatment of severe pancreatitis and septic shock,which can effectively improve the rescue success rate of patients,stabilize hemodynamics and myocardial enzyme profiles,and improve their immune function.
Imipenem and Cilastatin SodiumUlinastatinContinuous hemofiltrationSevere pancreatitisSeptic shockMyocardial zymogram
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