Observation on the Effect of Minimally Invasive Percutaneous Nephroscopy Combined with Ureteroscopic Holmium Laser Lithotripsy in the Treatment of Kidney Stones
Objective:To explore the therapeutic effect of minimally invasive percutaneous nephroscopy combined with ureteroscopic holmium laser lithotripsy on patients with kidney stones.Method:A total of 112 patients with kidney stones who received treatment at General Hospital of Central Theater Command of PLA from March 2021 to February 2023 were selected,they were divided into a control group(ureteroscopic holmium laser lithotripsy)and an observation group(ureteroscopic holmium laser lithotripsy combined with minimally invasive percutaneous nephroscopy)by random number table method,with 66 cases in each group.Perioperative indicators[surgery time,intraoperative bleeding volume,postoperative 1 day hemoglobin decrease rate,postoperative 1 day visual analogue scale(VAS)],inflammatory cytokine[interleukin-13(IL-13),procalcitonin(PCT),hypersensitive C reactive protein(hs-CRP)]levels,stress response[adrenocorticotropic hormone(ACTH),cortisol(Cor),norepinephrine(NE)],renal function indicators[blood urea nitrogen(BUN),serum creatinine(Scr),cystatin C(Cys C)],and incidence of complications were compared of two groups.Result:The surgical time of the control group was shorter than that of the observation group,the intraoperative bleeding volume was less than that of the observation group,and the postoperative 1 day hemoglobin decrease rate and VAS score were higher than those of the observation group,the differences were statistically significant(P<0.05).Before surgery,there were no statistically significant differences in the levels of IL-13,PCT,and hs-CRP between the two groups(P>0.05);after surgery,the levels of IL-13,PCT,and hs-CRP in both groups were increased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before surgery,there were no statistically significant differences in ACTH,Cor,and NE levels between the two groups(P>0.05);after surgery,the levels of ACTH,Cor,and NE in both groups were increased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before surgery,there were no statistically significant differences in BUN,Scr,and Cys C levels between the two groups(P>0.05);after surgery,BUN,Scr,and Cys C in both groups were increased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the control group was higher than that in the observation group,the difference was statistically significant(P<0.05).Conclusion:Patients with kidney stones who receive minimally invasive percutaneous nephroscopy combined with ureteroscopic holmium laser lithotripsy can reduce postoperative pain,alleviate inflammatory reactions,alleviate stress reactions,cause minimal damage to renal function,have high safety,and promote renal function recovery.
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