Progress of Research on Nanoparticle-based Delivery System for the Treatment of Sepsis
Sepsis is one of the most intractable critical illnesses worldwide.Early and adequate administration of sensitive antibiotics and symptomatic treatments such as vasopressors and fluid resuscitation are the prevalent treatments recommended by the current guidelines.However,due to the complex pathophysiological mechanism of sepsis and increasing antibiotic resistance,the mortality of sepsis reaches up to 30%-50%.The rapid development of nano-drug delivery technology has shed light on promising effectiveness on treatment of sepsis.In this review,several main types of nanoparticles researched today and the latest progress of these nanoparticles in the treatment of sepsis are reviewed.