Comparison of the Effect of LISA Technique and INSURE Technique in the Treatment of Respiratory Distress Syndrome of Preterm Infants
Objective:To discuss the application effect of two different administration methods of less invasive surfactant administration(LISA)and intubation-surfactant-extubate(INSURE)on respiratory distress syndrome(RDS)in preterm infants.Method:A total of 55 children with NRDS treated in Jiangxi Provincial Children's Hospital from January 1,2019 to August 31,2022 were divided into LISA group(given LISA technique,n=29)and INSURE group(given INSURE technique,n=26)by random number table method.Treatment related indexes and complications were compared between the two groups.Result:There was no significant difference in the utilization rate of secondary Calf Pulmonary Surfactant(CPS)between the two groups(P>0.05).The treatment rate of invasive mechanical ventilation within 72 h in LISA group was lower than that in INSURE group,and the mechanical ventilation time,total oxygen use time and hospital stay were shorter than those in INSURE group,the differences were statistically significant(P<0.05).The incidences of broncho-pulmonary dysplasia(BPD)and retinopathy of prematurity(ROP)in LISA group were lower than those in INSUR group,the differences were statistically significant(P<0.05),but there were no significant differences in the incidences of other complications between the two groups(P>0.05).Conclusion:Compared with INSURE technique,LISA technique can effectively reduce the mechanical ventilation rate,shorten the oxygen use time,and reduce the occurrence of BPD and ROP in the treatment of RDS in preterm infants.
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