Objective:To explore the relationship between platelet-to-albumin ratio(PAR)and clinicopathology of patients with IgA nephropathy(IgAN).Method:The clinicopathological data of 97 patients with primary IgAN who were diagnosed by renal puncture in the Department of Nephrology of the First People's Hospital of Lianyungang from June 2017 to December 2022 were collected retrospectively.Patients were categorized into two groups based on PAR percentile,49 patients in the low PAR group(≤5.63)and 48 patients in the high PAR group(>5.63).Result:The levels of PLT,cystatin C,blood uric acid,white blood cells and 24 h urinary protein in high PAR group were higher than those in low PAR group(P<0.05).Mesangial cell excess(M),capillary cell excess(E),renal tubule atrophy and interstitial fibrosis(T)in high PAR group were more than those in low PAR group(P<0.05).The serum albumin of high PAR group was lower than that of low PAR group(P<0.05).Pathologic grading in the low PAR group was dominated by grade Ⅰ+Ⅱ,while that in the high PAR group was dominated by grade Ⅳ+Ⅴ,the difference in pathologic grading between the two groups was statistically significant(字2=23.301,P<0.001).Conclusion:PAR may reflect the inflammatory state and activity of the disease in patients with IgA nephropathy,while IgAN patients with high PAR levels may be treated with more effective therapeutic regimens to improve renal outcomes.
关键词
IgA肾病/血小板与白蛋白比值/临床病理特征
Key words
IgA nephropathy/Platelet-to-albumin ratio/Clinicopathologic features
维普
万方数据