Effect of Fibrinogenase Injection Combined with Troxerutin for Injection in the Treatment of Acute Cerebral Infarction
Objective:To investigate the effect of Fibrinogenase Injection combined with Troxerutin for Injection in the treatment of acute cerebral infarction(ACI).Method:A total of 70 patients with ACI who were admitted to Yichun Second People's Hospital from January 2022 to August 2023 were selected as the study subjects,were divided into control group and observation group by random number table method,with 35 cases in each group.All patients were given Indobufen and Clopidogrel Bisulfate antiplatelet therapy and Atorvastatin treatment for stabilizing plaque.On this basis,the control group was treated with Troxerutin,the observation group was treated with Fibrinogenase Injection combined with Troxerutin.Clinical efficacy,neurological function,inflammatory factors and incidence of adverse reactions in the two groups were compared.Result:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).There were statistically significant differences in the national institutes of health stroke scale(NIHSS)scores of the two groups before treatment and after 1,7 and 10 d of treatment in terms of inter-group,time and interaction effect(P<0.05);after 1,7 and 10 d of treatment,the NIHSS scores of both groups were decreased compared to those before treatment,and the NHISS scores of the observation group were significantly lower than those of the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and hypersensitive C reactive protein(hs-CRP)in both groups were decreased compared to those before treatment,and the levels of IL-6,IL-8,and hs-CRP in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combined treatment of Fibrinogenase Injection and Troxerutin for Injection can achieve significant therapeutic effect on ACI as it can significantly improve the patients'neurological function and inflammatory response,with a low incidence of adverse reactions.
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