Effect of Aidi Injection Combined with mFOLFOX6 Regimen on T Lymphocyte Level and Safety of Chemotherapy in Patients with Advanced Colorectal Cancer
Objective:To study the value of Aidi Injection+mFOLFOX6 regimen in chemotherapy of advanced colorectal cancer.Method:A total of 90 patients with advanced colorectal cancer enrolled in Jiujiang NO.1 People's Hospital from July 2022 to March 2023 were selected and divided into two groups according to random number table method,with 45 cases respectively.The study group received Aidi Injection+mFOLFOX6 regimen,and the control group received mFOLFOX6 regimen.The toxic and side effects,syndrome scores,T lymphocytes,carbohydrate antigen 242(CA242),carbohydrate antigen 19-9(CA19-9),carcinoembryonic antigen(CEA),helper T cells(Th)1,Th2,Th1/Th2 and quality of life(QOL)were compared between the two groups.Result:The incidences of nausea,vomiting,constipation,diarrhea,myelosuppression and peripheral neurotoxicity in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in syndrome scores between the two groups before medication(P>0.05),and scores in the study group after medication were lower than those in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in T lymphocyte levels between the two groups before treatment(P>0.05),after treatment,the levels of CD3+,CD4+and CD4+/CD8+in the study group were higher than those in the control group,but level of CD8+was lower than that in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in levels of tumor markers between the two groups before treatment(P>0.05),and the levels of CA242,CA19-9 and CEA in the study group after treatment were lower than those in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in QOL scores between the two groups before medication(P>0.05),and QOL scores in the study group after medication were higher than those in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in levels of immune indexes between the two groups before medication(P>0.05),after medication,the levels of Th1 and Th1/Th2 in the study group were lower than those in the control group,but the level of Th2 was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Aidi Injection+mFOLFOX6 is more ideal in patients with advanced colorectal cancer,which can promote the improvement of T lymphocytes and tumor markers in patients,rapidly reduce symptoms,regulate immunity,improve quality of life,with less toxic side effects and higher safety.
万方数据
维普
