Effects of Butylphthalide and Sodium Chloride Injection and Urinary Kallidinogenase Combined with Intravenous Thrombolysis on Vascular Endothelial Function and Hemorrhagic Transformation in Patients with Acute Cerebral Infarction
Objective:To investigate the effect of Butylphthalide and Sodium Chloride Injection and Urinary Kallidinogenase combined with intravenous thrombolysis on vascular endothelial function and hemorrhagic transformation(HT)in patients with acute cerebral infarction(ACI).Method:A total of 120 patients with ACI diagnosed and treated in Nanchang People's Hospital from October 2020 to May 2023 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with intravenous thrombolysis and conventional treatment,the observation group was treated with Butylphthalide and Sodium Chloride Injection and Urinary Kallidinogenase on the basis of the control group.Vascular endothelial function,nerve function defect,hemorheology indexes and incidence of HT were evaluated and compared between the two groups.Result:After 2 weeks of treatment,the levels of vascular endothelial growth factor(VEGF)and nitric oxide(NO)increased and endothelin-1(ET-1)decreased in both groups,compared with the control group[(48.02±6.59)pg/mL,(38.58±5.40)μmol/L,(53.22±5.48)ng/L],VEGF,NO levels[(52.37±6.78)pg/mL,(42.46±6.21)μmol/L]in the observation group were higher,and ET-1 levels[(48.67±5.32)ng/L]was lower,the differences were statistically significant(P<0.05).After 1 and 2 weeks of treatment,the national institutes of health stroke scale(NIHSS)scores decreased in both groups,and those in the observation group[(7.65±1.55)scores,(4.83±1.25)scores]were significantly lower than those in the control group[(8.41±1.86)scores,(6.27±1.48)scores],the differences were statistically significant(P<0.05).After 2 weeks of treatment,whole blood viscosity,plasma viscosity and hematocrit decreased in both groups,and those in the observation group[(5.78±0.84)mPa·s,(1.18±0.19)mPa·s,(43.05±5.27)%]were significantly lower than those in the control group[(6.50±1.03)mPa·s,(1.33±0.21)mPa·s,(47.25±6.14)%],the differences were statistically significant(P<0.05).The incidence of HT in observation group and control group was 5.00%and 16.67%,respectively,there was statistical significance in the incidence of HT between the two groups(P<0.05).Conclusion:Butylphthalide and Sodium Chloride Injection and Urinary Kallidinogenase combined with intravenous thrombolysis can improve the vascular endothelial function of patients with ACI and reduce the risk of neurological damage and HT.
Butylphthalide and Sodium Chloride InjectionUrinary KallidinogenaseIntravenous thrombolysisAcute cerebral infarction
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