Effect of Intravenous Thrombolysis Combined with Dual Antiplatelet Therapy on AIS Patients and Its Influence on Nerve Function and TEG Parameters
Objective:To observe the efficacy,safety and effect of combined antiplatelet therapy on thromboelastography(TEG)after intravenous thrombolysis in patients with acute ischemic stroke(AIS).Method:In this study,90 patients with AIS admitted to Shenzhen Longgang District Third People's Hospital from February 2022 to May 2023 were selected,according to the different application of antiplatelet drugs after intravenous thrombolysis,they were randomly divided into three groups:low-dose group(Aspirin 100 mg),high-dose group(Aspirin 300 mg),combined drug group(Aspirin 100 mg+Clopidogrel 75 mg),30 cases in each group.The clinical effect,incidence of vascular recanalization and re-occlusion,adverse reactions during treatment,long-term recurrence rate,NIHSS score and TEG parameters were observed in three groups.Result:The total clinical effective rate of the combined drug group was higher than that of the low-dose group and high-dose group(P<0.05).The vascular recanalization rate in the combined drug group was significantly higher than that in the low-dose group in the acute phase of acute ischemic stroke(within 7 days of onset),the difference was statistically significant(P<0.05);the rate of vascular re occlusion in the combined drug group was significantly lower than that in the low-dose group and the high-dose group in the acute phase of acute ischemic stroke(within 7 days of onset),the differences were statistically significant(P<0.05);the incidence of adverse reactions during hospitalization in the combined drug group was significantly lower than that in the high-dose group,the difference was statistically significant(P<0.05);the recurrence rate of stroke within 90 days in the combined drug group was significantly lower than that in the low-dose group(P<0.05).There were significant differences in NIHSS scores among the three groups after 2 weeks of treatment(P<0.05),and the combined drug group was significantly lower than the low-dose group and the high-dose group,the differences were statistically significant(P<0.05);there were significant differences in NIHSS scores among the three groups after 90 days of treatment(P<0.05),and the combined drug group was significantly lower than that of the low-dose group and the high-dose group(P<0.05),and the high-dose group was significantly lower than that of the low-dose group(P<0.05).After treatment,the K value of high-dose group was longer than that of low-dose group(P<0.05),and the MA value of high-dose group was lower than that of low-dose group(P<0.05);the R value and K value in the combination group were longer than those in the high-dose group and the low-dose group,CI was higher than that in the high-dose group and the low-dose group(P<0.001),α angle and MA value were lower than those in the high-dose group and the low-dose group(P<0.05).Conclusion:Combined with dual antiplatelet therapy after intravenous thrombolysis can improve the clinical efficacy,reduce the recurrence rate and reduce the treatment risk in AIS patients.Antiplatelet aggregation therapy affects TEG parameters,and combined antiplatelet therapy may play a role by regulating TEG parameters.
万方数据
维普
