Comparison of Efficacy of Roxadustat and Recombinant Human Erythropoietin in the Treatment of Anemia of Stage 5 Chronic Kidney Disease
Objective:To observe and compare the therapeutic effects of Roxadustat and Recombinant Human Erythropoietin(rHuEPO)in patients with anemia of stage 5 chronic kidney disease(CKD).Method:Clinical data of 60 patients with anemia of stage 5 CKD treated in the Third People's Hospital of Jingdezhen from July 2021 to August 2022 were selected and divided into Roxadustat group and rHuEPO group according to different medication regimen,with 30 cases in each group.Clinical efficacy,blood routine,iron metabolism,levels of inflammatory factors and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of treatment in the Roxadustat group was significantly higher than that in the rHuEPO group(P<0.05).After treatment,hematocrit(Hct),hemoglobin(Hb)and serum Fe in both groups were increased compared to before treatment,and all above indexes in Roxadustat group were higher than those in another group,the differences were statistically significant(P<0.05).There were no significant differences in transferrin saturation(TSAT)between the two groups before and after treatment(P>0.05).After treatment,the levels of serum ferritin(SF),C reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in two groups were significantly lower compared with before treatment,and these were lower in Roxadustat group,the differences were statistically significant(P<0.05).During the observation period,the overall incidence of adverse reactions in Roxadustat group was slightly lower than that in rHuEPO group,the difference was not statistically significant(P>0.05).Conclusion:For patients with anemia of stage 5 chronic kidney disease,Roxadustat can significantly improve the level of hemoglobin,regulate iron metabolism,reduce inflammatory response,reduce adverse reaction rate,and the effect of improving anemia of stage 5 CKD is significantly higher than that of rHuEPO.
RoxadustatRecombinant Human ErythropoietinChronic kidney diseaseAnaemia
万方数据
维普
