Comparison of HFNC and NIPPV in Patients with AECOPD
Objective:To compare and analyze the application effect of high-flow nasal cannula(HFNC)and non-invasive positive pressure ventilation(NIPPV)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:Clinical data of 70 patients with AECOPD admitted to Department of Respiratory Medicine,Shangrao People's Hospital from May 2021 to October 2022 were retrospectively collected,and were divided into HFNC group(given HFNC supportive treatment)and NIPPV group(given NIPPV supportive treatment)according to different supportive treatment methods,with 35 cases in both groups.Both groups were intervened until they were discharged from hospital,and were followed up for 6 months.The clinical symptoms,respiratory frequency and blood gas indexes[partial pressure of oxygen in arterial blood(PaO2),arterial partial pressure of carbon dioxide(PaCO2),pH value]of the two groups were compared,and the complication rate and recurrence rate of the two groups were counted.Result:After 2 weeks of treatment,the classification modified British medical research council(mMRC)in HFNC group was better than that in NIPPV group,the difference was statistically significant(P<0.05).After 2 weeks of treatment,COPD assessment test(CAT)scores of both groups were decreased,and that in the HFNC group was significantly lower than that in the NIPPV group,the difference was statistically significant(P<0.05).After 48 hours of treatment,respiratory frequency and PaCO2 levels in both groups were decreased,and those in the HFNC group were significantly lower than those in the NIPPV group,the differences were statistically significant(P<0.05).After 48 hours of treatment,PaO2 and pH values of both groups were increased,and those in the HFNC group were significantly higher than those in the NIPPV group,the differences were statistically significant(P<0.05).The incidence of complications in HFNC group was significantly lower than that in NIPPV group,the difference was statistically significant(P<0.05).The patients were followed up for 6 months after discharge,there was no significant difference in recurrence rate between the two groups(P>0.05).Conclusion:Compared with NIPPV,HFNC can significantly improve clinical symptoms,respiratory rate and blood gas indexes in AECOPD patients,and the risk of complications is lower.
万方数据
维普
