Expression and Significance of GATA3 and SOX10 in Different Molecular Types of Breast Cancer
Objective:To investigate the expression characteristics and significance of GATA binding protein 3(GATA3)and sex determination region Y-box protein 10(SOX10)in different molecular types of breast cancer.Method:A total of 248 breast cancer samples stained with both SOX10 and GATA3 were collected from Department of Pathology,Guilin Maternal and Child Health Hospital from January 2021 to December 2022.The relationship between the expression of GATA3 and SOX10 in breast cancer and different clinicopathological features was analyzed.Result:The positive expression rates of GATA3 in breast cancer luminal A,luminal B,HER2 overexpression and TNBC were 100%,95.74%,93.75%and 37.88%respectively,there was significant difference in the positive expression rate among types(P<0.05);the positive expression rates of SOX10 in breast cancer luminal A,luminal B,HER2 overexpression and TNBC were 0,6.38%,9.38%and 78.78%respectively,there was significant difference in the positive expression rate among types(P<0.05).The positive expression rates of SOX10 and GATA3 in breast cancer luminal A,luminal B,HER2 overexpression and TNBC were 100%,97.87%,96.88%and 83.33%respectively,although the positive expression rate among the types was still statistically significant(P<0.05),the positive expression rate in breast cancer was 94.35%,which was significantly higher than that of GATA3(81.05%)and SOX10(24.60%)(P<0.05).The positive expression rate of GATA3+SOX10 in primary TNBC was as high as 84.48%(49/58),and the positive expression rate in metastatic TNBC was as high as 75.00%(6/8),there was no statistical significance between them(P>0.05).Conclusion:GATA3 has a high positive expression rate in luminal A,luminal B,and HER2 overexpression types of breast cancer,which is conducive to the evaluation and diagnosis of luminal and HER2 overexpression types of breast cancer lesions,and SOX10 has a high positive expression rate in TNBC,which is conducive to the diagnosis of TNBC.The combined application of SOX10 and GATA3 can improve the positive detection rate of breast cancer,and is beneficial to the diagnosis of metastatic TNBC biopsy samples with small tissue volume.
万方数据
维普
