The Effect of Metoprolol Succinate Sustained-release Tablets Combined with Fuxin Mixture in the Treatment of Coronary Artery Myocardial Bridging Angina and Its Impact on Vascular Endothelial Function
Objective:To explore the value of the combination of Metoprolol Succinate Sustained-release Tablets and Fuxin Mixture in the treatment of coronary artery myocardial bridging angina.Method:A total of 70 coronary artery myocardial bridging angina patients from February 2020 to October 2022 in Nanchang Hongdu Hospilal of TCM were selected as the study subjects,they were divided into two groups by random number table method,with 35 cases in each group.The control group was treated with Metoprolol Succinate Sustained-release Tablets,while the observation group was treated with Metoprolol Succinate Sustained-release Tablets combined with Fuxin Mixture.The clinical efficacy and incidence of adverse reactions between two groups were compared.Result:There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The clinical total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the comparison of heart function,vascular endothelial function,and incidence of angina between the two groups(P>0.05);after treatment,levels of nitric oxide(NO),reactive hyperemia index(RHI),left ventricular ejection fraction(LVEF),left ventricular fraction shortening(FS),ratio of peak E to peak A of mitral valve anterior blood flow in the observation group were higher compared to those the control group,6 minutes walking distance(6MWD)was longer than that in the control group;endothelin-1(ET-1),neuropeptide Y(NPY)in the observation group were lower than those in the control group,frequency of angina attack was lower than that in the control group,duration of angina attack was shorter than that in the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Metoprolol Succinate Sustained-release Tablets and Fuxin Mixture has an ideal therapeutic effect on coronary artery myocardial bridging angina.
Coronary artery muscle bridgingAnginaMetoprolol Succinate Sustained-release TabletsFuxin MixtureVascular endothelial function
万方数据
维普
