Observation on the Effect of Recombinant Human Interferon α1b Combined with Ambroxol Hydrochloride Aerosol Inhalation in the Treatment of Neonatal Pneumonia
Objective:To explore the clinical effect of Recombinant Human Interferon α1b combined with Ambroxol Hydrochloride atomized inhalation for neonatal pneumonia.Method:A total of 62 children with neonatal pneumonia admitted to Fujian Tingzhou Hospital were enrolled from June 2022 to June 2023 and divided into study group(n=31)and control group(n=31)by random number table method.The control group was treated with Ambroxol Hydrochloride aerosol inhalation,and the study group was treated with Recombinant Human Interferon α1b combined with Ambroxol Hydrochloride aerosol inhalation.The total clinical effective rate,duration of disappearance of clinical symptoms,level of inflammatory factors,blood gas index and incidence of adverse reactions were compared between the two groups.Result:The total clinical effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms in the study group were earlier than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of inflammatory factors in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the partial oxygen pressure(PaO2)and oxygenation index in the study group were higher than those in the control group,and the partial carbon dioxide pressure(PaCO2)was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Recombinant Human Interferon α1b combined with Ambroxol Hydrochloride atomized inhalation in the treatment of neonatal pneumonia has a remarkable effect,which can shorten the time of clinical symptoms to disappear,relieve inflammation,improve blood gas indexes,and no serious adverse reactions after medication.
Recombinant Human Interferon α1bAmbroxol HydrochlorideNeonatal pneumonia
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