Effect of rTMS Combined with Sertraline on Cognitive Function in Adolescent Patients with First-episode Depression and Somatic Pain
Objective:To explore the effects of repetitive transcranial magnetic stimulation(rTMS)combined with Sertraline on cognitive function in adolescents with first-episode depression and somatic pain.Method:A total of 80 adolescents with first-episode depression and somatic pain admitted to the Third People's Hospital of Ganzhou were enrolled from October 2022 to September 2023.According to random number table method,they were divided into observation group(n=40)and control group(n=40).The control group was treated with Sertraline,while observation group was additionally treated with rTMS.Clinical effect,scores of numerical rating scale(NRS),Hamilton depression scale 17-item(HAMD-17),Hamilton anxiety scale(HAMA),Montreal cognitive assessment(MoCA)and clinical memory scale(CMS),and the incidence of adverse reactions in the two groups were recorded and compared.Result:The total effective rate of treatment in observation group was 95.00%,which was significantly higher than 77.50%in control group(P<0.05).After treatment,scores of NRS,HAMD-17 and HAMA in both groups were decreased compared to those before treatment,those in the observation group were lower than those in control group(P<0.05);the scores of MoCA and CMS in both groups were increased compared to those before treatment,those in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:rTMS combined with Sertraline can relieve somatic pain and improve cognitive function in adolescents with depression.
First-episode depressionRepetitive transcranial magnetic stimulationSertralineSomatic painCognitive function
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