目的:探讨阿替普酶(rt-PA)静脉溶栓联合丁苯酞用于急性脑梗死(acute cerebral infarction,ACI)患者治疗中的临床效果.方法:以 2022 年 1 月—2023 年 6 月瑞金市人民医院收治的ACI患者 82 例为研究对象,按随机数字表法分为对照组(脑梗死常规治疗+rt-PA静脉溶栓)、观察组(在对照组基础上联合应用丁苯酞),每组 41 例.观察对比两组神经功能缺损程度、生活自理能力、临床疗效、血清指标、不良反应发生率及生活质量评分.结果:治疗后两组美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分较治疗前均降低,日常生活活动能力量表(activities of daily living,ADL)、健康调查简易量表(SF-36)评分较治疗前均升高,且观察组均优于对照组,差异均有统计学意义(P<0.05);观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05);治疗后两组脑钠肽(brain natriuretic peptide,BNP)、同型半胱氨酸(homocysteine,Hcy)、C反应蛋白(C reactive protein,CRP)水平均较治疗前降低,且观察组均低于对照组,差异均有统计学意义(P<0.05).结论:ACI患者应用rt-PA静脉溶栓联合丁苯酞治疗,临床效果确切,且安全性高,可促进神经功能恢复,改善预后.
Effect Analysis of rt-PA Intravenous Thrombolysis Combined with Butylphthalide in Patients with Acute Cerebral Infarction
Objective:To investigate the clinical effects of Alteplase(rt-PA)combined with Butylphthalide in the treatment of acute cerebral infarction(ACI).Method:A total of 82 patients with ACI admitted to Ruijin People's Hospital from January 2022 to June 2023 were divided into two groups:control group(conventional treatment of cerebral infarction+rt-PA intravenous thrombolysis)and observation group(combined application of Butylphthalide on the basis of control group),with 41 cases in each group.The degree of neurological impairment,self-care ability,clinical efficacy,serum indexes,incidence of adverse reactions and quality of life score of the two groups were observed and compared.Result:After treatment,the national institutes of health stroke scale(NIHSS)scores in both groups were lower than those before treatment,the scores of activities of daily living(ADL)and the MOS item short form health survey(SF-36)were all increased compared with those before treatment,the observation group were superior to the control group,the differences were statistically significant(P<0.05).The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of brain natriuretic peptide(BNP),homocysteine(Hcy)and C reactive protein(CRP)in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:rt-PA intravenous thrombolysis combined with Butylphthalide therapy in ACI patients has definite clinical effect and high safety,which can promote the recovery of nerve function and improve the prognosis.
rt-PA intravenous thrombolysisButylphthalideAcute cerebral infarctionNeurological functionQuality of life
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维普
