Application of Vibration Sputum-discharge Apparatus Combined with Ipratropium Bromide and Salbutamol for Aerosol Inhalation in the Treatment of Silicosis and COPD
Objective:To explore the application of vibration sputum-discharge apparatus combined with Ipratropium Bromide and Salbutamol for aerosol inhalation in the treatment of silicosis and chronic obstructive pulmonary disease(COPD).Method:A total of 76 patients with silicosis complicated with COPD were selected from General Hospital of Pingxiang Mining Group Co.from June 2021 to June 2023 for the study.According to the order of admission,patients were divided into observation group and control group by computer random number grouping method,with 38 cases in each group.All patients received routine anti infection and symptomatic treatment for asthma and spasms,the control group was treated with vibration sputum-discharge apparatus and Ipratropium Bromide on this basis,while observation group was additionally treated with Salbutamol on basis of control group.The clinical effieacy,recovery indexes(remission time of lung signs and cough,hospitalization time),sputum output,pulmonary function[the percentage of maximalmid-expiratory flow velocity in vital capacity 50%to predicted value(MEF50%pred),forced vital capacity(FVC),the percentage of forced expiratory volume in 1 second to forced vital capacity(FEV1/FVC%)],inflammatory indexes[interleukin-6(IL-6),procalcitonin(PCT),serum amyloid A(SAA)],arterial blood gas indexes[partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SaO2)]and occurrence of adverse reactions in the two groups were compared.Result:The total effective rate of treatment in observation group was 92.11%,which was higher than 73.68%in control group,the difference was statistically significant(P<0.05).The remission time of lung signs and cough,and hospitalization time in observation group were shorter compared to those the control group,the differences were statistically significant(P<0.05).After 3,7 d of treatment,daily sputum output in observation group were than those in control group,the differences were statistically significant(P<0.05).After treatment,MEF50%pred,FVC,FEV1/FVC%,PaO2 and SaO2 in observation group were higher than those in control group,the differences were statistically significant(P<0.05);while IL-6,PCT,SAA and PaCO2 in observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Curative effect of vibration sputum-discharge apparatus combined with Ipratropium Bromide and Salbutamol for aerosol inhalation is good in patients with silicosis and COPD.
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