Diagnostic Value of Color Doppler Ultrasound Combined with miR-222 and miR-21 in Senile Degenerative Heart Valvular Disease
Objective:To explore the diagnostic value of color Doppler ultrasound combined with microRNA-222(miR-222)and microRNA-21(miR-21)in senile degenerative heart valvular disease.Method:A total of 100 patients who were examined in Longnan First People's Hospital from June 2022 to June 2023 due to discomfort(palpitation,force,chest pain,etc.)were selected as the study group,taking comprehensive clinical diagnosis as the gold standard,58 patients diagnosed with senile degenerative heart valvular disease were selected as the valvular heart disease group.In addition,90 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the normal group.All patients underwent color Doppler ultrasonography and the expression levels of miR-222 and miR-21 were detected.The expression levels of miR-222 and miR-21 were compared between the valvular heart disease group and the normal group and patients with different severity of valvular dysfunction.The value of combination of color Doppler ultrasound,miR-222 and miR-21 in the diagnosis of senile degenerative heart valvular disease were analyzed.Result:The diagnostic accuracy,sensitivity and specificity of color Doppler ultrasound for senile degenerative heart valvular disease were 84.00%(84/100),82.76%(48/58)and 85.71%(36/42)respectively.Compared with the normal group,the expression levels of miR-222 and miR-21 in the heart valvular disease group were significantly higher(P<0.05).The expression levels of miR-222 and miR-21 in patients with severe valvular dysfunction were significantly higher than those in mild and moderate patients,the expression levels of miR-222 and miR-21 in patients with moderate valvular dysfunction were significantly higher than those in mild and moderate patients(P<0.05).Receiver operating characteristics(ROC)curve analysis showed that the area under the curve(AUC)of the three combinations for the diagnosis of senile degenerative heart valvular disease was higher than that of the single diagnosis.Conclusion:The expression levels of miR-222 and miR-21 are high in senile degenerative heart valvular disease,and the expression levels of miR-222 and miR-21 gradually increase with the severity of the disease.The combined examination of color Doppler ultrasound,miR-222 and miR-21 have high diagnostic value and can be used in the clinical diagnosis of senile degenerative heart valvular disease.
Color Doppler ultrasoundmicroRNA-222microRNA-21Senile degenerative heart valvular disease
万方数据
维普
