Effects of Dexmedetomidine Combined with Parecoxib Sodium on Levels of Inflammatory Factors and Pulmonary Oxygenation in Patients with Single Lung Ventilation after Thoracoscopic Radical Resection of Lung Cancer
Objective:To investigate the effects of Dexmedetomidine combined with Parecoxib Sodium on the levels of inflammatory factors and pulmonary oxygenation in patients with single lung ventilation after thoracoscopic radical resection of lung cancer.Method:A total of 192 patients with single lung ventilation who underwent thoracoscopic radical resection for lung cancer treated in Hai'an Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected and divided into three groups by random number table method.Dexmedetomidine group(n=58)was given 1 μg/kg Dexmedetomidine intravenically 20 min before anesthesia induction,after that,a maintenance dose of 0.6 μg/(kg·h)was administered to the chest.The Parecoxib Sodium group(n=58)was given 40 mg of Parecoxib Sodium intravenously 20 minutes before induction of anesthesia,and the compound group(n=76)was given Dexmedetomidine combined with Parecoxib Sodium intravenously.The levels of inflammatory factors,pulmonary oxygenation index and pain degree of the three groups were compared at different time points,and the occurrence of adverse reactions in the three groups were recorded.Result:After 30 min of single lung ventilation(T1)and after surgery(T2),the levels of serum CRP,TNF-α and IL-1β in three groups were higher than those before anesthesia induction(T0),the differences were statistically significant(P<0.05),however,the above indexes of T1 and T2 in the compound group were lower than those in Dexmedetomidine group and Parecoxib Sodium group,the differences were statistically significant(P<0.05),at T1 and T2,there were no significant differences in the above indexes between the Dexmedetomidine group and the Parecoxib Sodium group(P>0.05).At T1 and T2,PaO2 and OI levels of the three groups were decreased compared with T0,and PaCO2 levels were increased compared with T0,the differences were statistically significant(P<0.05);however,PaO2 and OI at T1 and T2 of compound group were higher than those in Dexmedetomidine group and Parecoxib Sodium group,and PaCO2 levels were lower than those in Dexmedetomidine group and Parecoxib Sodium group,the differences were statistically significant(P<0.05);at T1 and T2,there were no significant differences in the above indexes between Dexmedetomidine group and Parecoxib Sodium group(P>0.05).At 2,6 and 24 h after surgery,VAS scores in the compound group were lower than those in Dexmedetomidine group and Parecoxib Sodium group,the differences were statistically significant(P<0.05);there were no significant differences in VAS scores between Dexmedetomidine group and Parecoxib Sodium group at each time point(P>0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Dexmedetomidine combined with Parecoxib Sodium can reduce the levels of inflammatory factors and postoperative pain in patients with single lung ventilation after thoracoscopic radical lung cancer surgery,the impact of oxygenation function is minimal.
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