Clinical Effect of Sitz Bath with Qingre Zhidai Prescription Combined with Live Lactobacillus Capsules in the Treatment of Postmenopausal Atrophic Vaginitis with Pattern of Dampness-heat Diffusing Downward and Its Influence on Sex Hormone
Objective:To investigate the clinical effect of sitz bath with Qingre Zhidai Prescription combined with Live Lactobacillus Capsules in the treatment of postmenopausal atrophic vaginitis with pattern of dampness-heat diffusing downward and its influence on sex hormone.Method:A total of 130 patients with postmenopausal atrophic vaginitis with pattern of dampness-heat diffusing downward treated in Weifang Hospital of Traditional Chinese Medicine from April 2019 to November 2022 were selected and randomly divided into control group(n=65)and observation group(n=65).The control group was given Live Lactobacillus Capsules,and the observation group was given Qingre Zhidai Prescription sitz bath on the basis of Live Lactobacillus Capsules.Both groups were treated for 4 weeks.The clinical efficacy,sex hormone[follicle-stimulating hormone(FSH),estradiol(E2)],immune function indexes[immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin A(IgA)],inflammatory factors[interleuin-8(IL-8),interleukin-4(IL-4)and C reactive protein(CRP)]in vaginal discharge and adverse reactions were compared between the two groups.Result:The total effective rate of observation group(95.38%)was higher than that of control group(84.62%)(P<0.05).After treatment,FSH were decreased and E2 were increased in both groups,FSH in observation group was lower than that in control group,while E2 was higher than that in control group(P<0.05).After treatment,the levels of IgM,IgG and IgA in both groups were increased,and the levels of IgM,IgG and IgA in observation group were higher than those in control group(P<0.05).After treatment,the levels of IL-8,IL-4 and CRP in vaginal discharge of both groups were decreased,and the levels of IL-8,IL-4 and CRP in observation group were lower than those in control group(P<0.05).The incidence of adverse reactions in observation group(6.15%)was lower than that in control group(18.46%)(P<0.05).Conclusion:The effect of sitz bath with Qingre Zhidai Prescription combined with Live Lactobacillus Capsules in the treatment of postmenopausal atrophic vaginitis with pattern of dampness-heat diffusing downward is exact,which can improve sex hormones and immune function,inhibit vaginal inflammatory reaction,and have good safety.
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