Safety of Bushen Tiaogan Decoction Combined with GnRH-a in the Treatment of Endometriosis and Its Influence on Perimenopausal Syndromes
Objective:To evaluate the safety of Bushen Tiaogan Decoction combined with gonado-tropin-releasing hormone agonist(GnRH-a)in the treatment of endometriosis(EMT)and its influence on perimenopausal syndromes.Method:Clinical data of 306 patients with EMT admitted to Department of Obstetrics and Gynecology,Baotou Mongolian Medicine Hospital of Traditional Chinese Medicine from January 2019 to January 2022 were retrospectively analyzed.They were divided into control group(treated with Triptorelin Acetate)and combination group(Bushen Tiaogan Decoction+Triptorelin Acetate)according to different treatment methods,with 153 cases in each group.The therapeutic effect,pain degree,safety and recurrence rate of the two groups were statistically compared.Result:The total effective rate of combination group was 91.50%,which was significantly higher than that of control group(81.70%)(P<0.05).The visual analogue scale(VAS)scores of chronic pelvic pain,dysmenorrhea and dyspareunia in the two groups after treatment were significantly lower than those before treatment,and the VAS scores of chronic pelvic pain,dysmenorrhea and dyspareunia in the combination group were significantly lower than those in the control group(P<0.05).The incidences of perimenopausal syndromes in the combination group were significantly lower than those in the control group(P<0.05).There were no significant differences in the incidences of other adverse reactions between the two groups(P>0.05).The recurrence rate in combination group was significantly lower than that in control group(P<0.05).Conclusion:Bushen Tiaogan Decoction combined with GnRH-a is effective in the treatment of EMT,which can relieve the pain of patients,reduce the perimenopausal syndromes,the incidence of adverse reactions and the recurrence rate.
国家科技期刊平台
NSTL
万方数据
