Analysis of the Effect of Compound Danshen Dripping Pills Combined with Clopidogrel in the Treatment of Stable Angina in Coronary Heart Disease
Objective:To explore the effect of Compound Danshen Dripping Pills combined with Clopidogrel in the treatment of stable angina pectoris in coronary heart disease.Method:A total of 98 patients with stable angina pectoris of coronary heart disease who were treated in Kweichow Moutai Hospital from May 2021 to April 2023 were selected,they were divided into control group(Clopidogrel)and observation group(combined with Compound Danshen Dripping Pills)by random number table method,with 49 cases in each group.The changes in 24-hour dynamic electrocardiogram[number and duration of ischemic attacks],vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1),vascular endothelial growth factor(VEGF),soluble thrombomodulin(sTM)],cardiac autonomic function[low-frequency power/high-frequency power(LF/HF),RR interval standard deviation(SDNN),root mean square of adjacent NN interval difference(RMSSD)],oxidative stress response[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)]were compared between two groups.Result:Before treatment,there were no statistically significant differences in the 24-hour electrocardiogram changes between the two groups(P>0.05);after treatment,the number of ischemic attacks in both groups were decreased compared to those before treatment,the duration of ischemia in both groups was shortened compared to those before treatment,those in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in NO,VEGF,ET-1 and sTM between the two groups(P>0.05);after treatment,the levels of NO and VEGF in both groups were increased compared to those before treatment,while ET-1 and sTM were decreased,NO and VEGF in the observation group were higher than those in the control group,ET-1 and sTM were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in LF/HF,SDNN and RMSSD between the two groups(P>0.05);after treatment,LF/HF,SDNN and RMSSD in both groups were increased compared to those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in SOD,GSH-Px and MDA between the two groups(P>0.05);after treatment,MDA levels in both groups were decreased compared to those before treatment,while SOD and GSH-Px levels were increased.MDA level in the observation group was lower than that in the control group,while SOD and GSH-Px levels were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Compound Danshen Dripping Pills and Clopidogrel in the treatment of stable angina pectoris in coronary heart disease can improve myocardial ischemia,reduce oxidative stress response,and improve vascular endothelial and cardiac autonomic function.
Compound Danshen Dripping PillsClopidogrelCoronary heart disease stable anginaVascular endothelial function
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