Evaluation Value of Serum Thyroid Hormones in Condition and Prognosis of Patients with Chronic Hepatitis B
Objective:To study the significance of serum thyroid hormones detection in condition and prognosis evaluation of patients with chronic hepatitis B.Method:A retrospective analysis of 80 patients with chronic hepatitis B who were treated in Jiujiang Third People's Hospital from April 2021 to May 2023 were selected as the study group,and 30 healthy volunteers who received physical examination in the our hospital during the same period were selected as the control group,the study group received 3 months of conventional antiviral treatment.Serum thyroid hormone levels in the study group before treatment were compared with those in the control group.Serum thyroid hormone levels in patients with different severity of chronic hepatitis B before treatment were compared.Spearman correlation analysis was conducted to discuss the correlation between serum thyroid hormone levels and the severity of chronic hepatitis B.Serum thyroid hormone levels in patients with different prognoses were recorded,and the serum thyroid hormone levels of chronic hepatitis B patients with different prognosis were compared.The prognostic value of serum thyroid hormone levels in patients with chronic hepatitis B was analyzed by receiver operating characteristic(ROC)curve.Result:There were no statistically significant differences in the levels of free triiodothyronine(FT3)and free thyroxine(FT4)between the study group and the control group(P>0.05);the level of thyroid stimulating hormone(TSH)in the study group was lower than that in the control group(P<0.05).There were no statistically significant differences in FT3 or FT4 among patients with different severity of chronic hepatitis B(P>0.05);there was statistically significant difference in serum TSH(P<0.05);TSH level in severe group was lower than that in moderate group and mild group,and the level of TSH in moderate group was lower than that in mild group(P<0.05).Spearman correlation analysis found that TSH was negatively correlated with the condition of patients with chronic hepatitis B(rs=-0.654,P<0.01).After treatment,hepatitis B surface antigen(HBsAg)in 11 cases turned negative were included in the HBsAg clearance group,and the other 69 cases were included in the non-HBsAg clearance group.TSH in HBsAg clearance group was significantly higher than that in the non-HBsAg clearance group(P<0.05).There were no statistically significant differences in serum FT3 or FT4 between patients with different prognoses(P>0.05).ROC curve indicated that the AUC of TSH level to predict the prognosis of chronic hepatitis B was 0.629(P=0.114).Conclusion:Detecting serum thyroid hormone TSH levels in patients with chronic hepatitis B can be used as important reference for condition evaluation.However,the relationship with the prognosis of antiviral treatment in patients with chronic hepatitis B needs further study.
Thyroid hormoneHepatitis BHepatitis B surface antigenPrognosis
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