摘要
目的:研究感染相关因子单项及联合诊断对小儿肠炎感染类型的鉴别价值.方法:选取2021 年 1 月—2023 年 4 月于上饶市立医院就诊的小儿肠炎感染患儿 90 例,根据轮状病毒试验结果及微生物实验室结果,将细菌性感染患儿 45 例纳入细菌组,将病毒性感染患儿 45 例纳入病毒组,比较两组患儿的感染相关因子[白细胞(WBC)、中性粒细胞(NEUT)、淋巴细胞(LYM)、C反应蛋白(CRP)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、淀粉样蛋白A(SAA)]水平变化,以受试者操作曲线(ROC)曲线评估感染相关因子单项及联合诊断小儿肠炎感染类型的价值.结果:细菌组患儿的WBC、NEUT、CRP、hs-CRP、PCT均显著高于病毒组,差异均有统计学意义(P<0.05),细菌组患儿的LYM和SAA均显著低于病毒组,差异均有统计学意义(P<0.05).感染相关因子WBC、NEUT、LYM、CRP、hs-CRP、PCT、SAA单项诊断小儿肠炎感染类型的曲线下面积(AUC)分别为 0.681、0.754、0.828、0.711、0.741、0.669、0.796,敏 感 度 分 别 为 57.78%、93.33%、77.78%、51.11%、60.00%、40.00%、93.33%,特异度分别为 77.78%、62.22%、75.56%、88.89%、97.78%、93.33%、57.78%;感染相关因子联合诊断小儿肠炎感染类型的AUC为 0.970,敏感度为 93.33%,特异度为 91.11%.结论:WBC、NEUT、CRP、hs-CRP、PCT在小儿肠炎细菌感染患儿体内高水平表达,且较病毒感染患儿更高,而细菌组患儿的LYM和SAA的表达水平显著低于病毒感染患儿,其联合诊断对于小儿肠炎具有重要的临床参考价值.
Abstract
Objective:To study the identification value of single blood routine indicator and combined diagnosis on types of enteritis infection in children.Method:A total of 90 children with enteritis infection in Shangrao Municipal Hospital from January 2021 to April 2023 were selected.According to the results of rotavirus test and microbiology laboratory,45 pediatric patients with bacterial infection were included in bacterial group,and 45 pediatric patients with viral infection were enrolled as viral group.The two groups were compared in terms of infection-related factors[white blood cell(WBC),neutrophil(NEUT),lymphocyte(LYM),C reactive protein(CRP),hypersensitive C reactive protein(hs-CRP),procalcitonin(PCT),serum amyloid A(SAA)].Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of single and combined infection-related factors in the diagnosis of enteritis infection type in children.Result:WBC,NEUT,CRP,hs-CRP and PCT in bacterial group were significantly higher than those in viral group(P<0.05),while LYM and SAA were significantly lower than those in viral group(P<0.05).The areas under the curves(AUC)of WBC,NEUT,LYM,CRP,hs-CRP,PCT and SAA in the diagnosis of enteritis infection type in children were 0.681,0.754,0.828,0.711,0.741,0.669 and 0.796,the sensitivities were 57.78%,93.33%,77.78%,51.11%,60.00%,40.00%and 93.33%,and the specificities were 77.78%,62.22%,75.56%,88.89%,97.78%,93.33%and 57.78%respectively.The AUC,sensitivity and specificity of the combination of infection-related factors in the diagnosis of enteritis infection type in children were 0.970,93.33%and 91.11%.Conclusion:WBC,NEUT,CRP,hs-CRP and PCT are highly expressed in children with enteritis bacterial infection,and the above expression levels are higher than those in children with virus infection,while the expression levels of LYM and SAA of children with bacterial infection are significantly lower compared to children with virus infection.The combined diagnosis of the above indicators has important clinical reference value on children with enteritis.
国家科技期刊平台
NSTL
万方数据