Comprehensive Analysis of Screening Results of Glucose-6-phosphate Dehydrogenase Deficiency in 68,308 Newborns in Zhaoqing City
Objective:To analyze the screening results of glucose-6-phosphate dehydrogenase(G6PD)deficiency in 68,308 newborns in Zhaoqing City.Method:A total of 68,308 newborns born in Zhaoqing City from January 2021 to December 2022 were selected as the research objects.Heel blood of all newborns were collected,and G6PD deficiency was prescreened by fluorimetry,and suspected positive children were recalled,and venous blood were collected for diagnosis by continuous monitoring.Result:In 2021,a total of 35,610 newborns were screened,and 3,580 were positive in the prescreening,accounting for 10.05%(3,580/35,610).In 2022,a total of 32,698 newborns were screened,and 2,983 were positive in the prescreening,accounting for 9.12%(2,983/32,698).6,563 positive in the prescreening were examined for confirmation,of which 2,585 were confirmed in 2021 and 2,153 were confirmed in 2022,a total of 4,738 cases of G6PD deficiency were confirmed,the confirmed rate was 6.94%(4,738/68,308).Among the 6,563 positive cases,5,186 were baby boys and 1,377 were baby girls.Among baby boys with positive in prescreening,3,829 cases were diagnosed,the diagnosis rate was 5.61%(3,829/68,308).Among baby girls with positive in prescreening,909 cases were diagnosed,the diagnosis rate was 1.33%(909/68,308).Positive diagnosis rate of primary screening of baby boys was higher than that of baby girls,the difference was statistically significant(字2=33.148,P<0.05).Among the 4,738 cases of G6PD deficiency,1,130 cases were severe deficiency,accounting for 23.85%(1,130/4,738),1,067 cases were moderate deficiency,accounting for 22.52%(1,067/4,738),and 2,541 cases were mild deficiency,accounting for 53.63%(2,541/4,738).Conclusion:Among 68,308 newborns in Zhaoqing City,G6PD deficiency is mainly in baby boys,and most of the cases are mild deficiency.
国家科技期刊平台
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