Effects of Roxadustat on Patients with Renal Anemia after Maintenance Hemodialysis
Objective:To explore the effects of Roxadustat on patients with renal anemia after maintenance hemodialysis(MHD).Method:A total of 80 patients with renal anemia undergoing MHD in Nephrology Department of Pingxiang People's Hospital were enrolled from January 2021 to September 2023,they were divided into observation group(n=40)and control group(n=40)by 1∶1 random number table method.The observation group was treated with Roxadustat,while the control group was treated with Human Erythropoietin,both were lasted for 6 months.The clinical effect,blood routine indicators[hemoglobin(Hb),red blood cell count(RBC),hematocrit(HCT)],iron metabolism indexes[serum iron(Fe),total iron binding capacity(TIBC),transferrin saturation(TSAT)],serum prealbumin(PAB),albumin(Alb)and inflammation indicators[C reactive protein(CRP)]in the two groups was compared.The adverse reactions in the two groups during treatment were recorded.Result:The total effective rate of clinical treatment in observation group was higher than that in control group,the difference was statistically significant(P<0.05).After treatment,Hb,RBC and HCT in observation group were higher than those in control group,the differences were statistically significant(P<0.05);levels of Fe,TIBC and TSAT were higher than those in control group,the differences were statistically significant(P<0.05);there were no significant differences in serum PAB and Alb between the two groups(P>0.05);CRP level in observation group was lower than that in control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between observation group(10.00% )and control group(15.00% )(P>0.05).Conclusion:Both Roxadustat and Human Erythropoietin have certain clinical effect in MHD patients with renal anemia.However,Roxadustat has more obvious correction effect on renal anemia after MHD,which can effectively improve metabolic function and relieve inflammatory response,with good safety.
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