The Effect of Xuefu Zhuyu Pills Combined with Adductor Canal Block on Postoperative Inflammatory Factors in Patients Undergoing Total Knee Arthroplasty and Its Application in Myocardial Protection
Objective:To investigate the effect of Xuefu Zhuyu Pills combined with adductor canal block on postoperative inflammatory factors in patients with total knee arthroplasty and its application effect in myocardial protection.Method:A total of 88 patients who underwent elective total knee arthroplasty in Ganzhou People's Hospital from December 2021 to June 2023 were selected,the patients were randomly divided into experimental group(n=46)and control group(n=42),and both groups underwent general anaesthesia by tracheal intubation,on which the experimental group was treated with adductor canal block combined with Xuefu Zhuyu Pills,while the control group only used conventional intravenous analgesic pumps.The control group only used conventional intravenous analgesic pump.The analgesic effect,inflammatory factor,myocardial injury markers and cardiac function indexes before and after surgery were compared between the two groups.Result:The satisfaction rate of analgesia in the experimental group was 78.26%,which was higher than 57.14% in the control group,the difference was statistically significant(P<0.05).Before anesthesia induction(T0),14 d after surgery(T4),there were no significant differences in the levels of hypersensitive C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive troponin(hs-cTn)and creatine kinase isoenzyme(CK-MB)between the two groups(P>0.05);1 d after surgery(T1),4 d after surgery(T2),7 d after surgery(T3),the levels of hs-CRP,TNF-α,IL-6,hs-cTn and CK-MB in experimental groups were lower than those in control group,the differences were statistically significant(P<0.05).at T0 and T4 time points,the two groups had lower left ventricular diastolic volume(EDV),per beat output(SV)levels were compared,the differences were not statistically significant(P>0.05);while at T1 and T3 time points,the levels of EDV,SV and and ejection fraction(EF)of the experimental group were higher than those of the control group,the EF of T4 in experimental group was higher than that in control group,the differences were statistically significant(P<0.05).Conclusion:Xuefu Zhuyu Pills combined with adductor canal block can improve the analgesic effect of total knee arthroplasty patients,effectively inhibit the level of inflammatory factors and reduce the damage of cardiomyocytes,and improve the cardiac function.
Total knee replacementAdductor canal blockXuefu Zhuyu PillsInflammatory factorsMyocardial protection
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