Effects of Dapagliflozin Combined with Insulin Glargine on Renal Function Indexes and Blood Glucose Control in Patients with Early Diabetic Nephropathy
Objective:To investigate the effect of Dapagliflozin combined with Insulin Glargine in early diabetic nephropathy patients.Method:A total of 108 patients with early diabetic nephropathy admitted to Jingdezhen Second People's Hospital from December 2021 to December 2023 were divided into two groups according to random number table method,with 54 patients in each group.The control group was treated with Insulin Glargine,and the observation group was treated with Dapagliflozin on the basis of control group.The clinical efficacy,renal function index,blood glucose index and the occurrence of adverse reactions were observed and compared between the two groups.Result:The total effective rate of the observation group was 90.74%,which was higher than 72.22% of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of blood urea nitrogen(BUN),blood creatinine(Scr),urinary microalbumin(mALB)and urinary albumin to creatinine ratio(ACR)in both groups were lower than those before treatment,the estimated glomerular filtration rate(eGFR)was significantly higher than that before treatment,and BUN,Scr,mALB and ACR in observation group were lower than those in control group,and eGFR was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,the levels of glycated hemoglobin(HbA1c),fasting blood glucose(FBG),daily mean amplitude of glycemic excursions(MAGE)and 2 h postprandial blood glucose(2 h PG)in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(字2=1.582,P=0.207).Conclusion:Dapagliflozin combined with Insulin Glargine has a definite effect in the treatment of elderly diabetic nephropathy patients,which can effectively regulate blood glucose level and facilitate the recovery of renal function with good safety.
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