Effect of Different Timing of Enteral Nutritional Support on T-lymphocyte Th17/Treg Ratio and Clinical Prognosis in Mechanically Ventilated Patients with Sepsis
Objective:To explore the effects of different timing of enteral nutritional support on T-lymphocyte Th17/Treg ratio and clinical prognosis in mechanically ventilated patients with sepsis.Method:Sixty-two patients admitted to the ICU of the Affiliated Hospital of Jiujiang College with a confirmed diagnosis of sepsis undergoing mechanical ventilation between August 2022 and December 2023 were selected and randomly divided into the early group(n=31)as well as the conventional group(n=31).In the early group,nutritional support was given within 24 h of admission,while in the conventional group,nutritional support was given within 48-72 h of admission.Interleukin(IL-6),interleukin(IL-10),Th17 and Treg levels were measured at admission and after 7 days of treatment,and the Th17/Treg ratio was calculated,as well as the acute physiology and chronic health score(APACHEⅡ score)before and after treatment and the duration of mechanical ventilation in the two groups.Result:After 7 days of treatment,the IL-6,Th17 level,Th17/Treg ratio of the early group were significantly lower than those of the conventional group(P<0.05),whereas there were no significant differences in the IL-10 level and the Treg level of the two groups after 7 days of treatment(P>0.05);for comparison of clinical indicators,after 7 days of treatment,the albumin(ALB)and preprotein(PA)levels of the early group were significantly higher than those of the conventional group,and the PCT level of the early group was significantly lower than that of the conventional group,the mechanical ventilation time of the early group was significantly shorter than that of the conventional group,and APACHEⅡ score of the early group was significantly lower than that of the conventional group,the differences were statistical significant(P<0.05).Conclusion:In the case of hemodynamic stabilization of mechanically ventilated patients with sepsis,early administration of appropriate amount of enteral nutritional support can reduce the T-lymphocyte Th17/Treg ratio,attenuate the inflammatory response of patients with sepsis,and improve the therapeutic efficacy of patients.
Early nutritional supportSepsisMechanical ventilationTh17/Treg ratio
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