The Effect of Longqing Capsules Combined with Tamsulosin Hydrochloride in the Treatment of Chronic Nonbacterial Prostatitis with Damp Heat Infusion Type
Objective:To observe the effect of Longqing Capsules combined with Tamsulosin Hydrochloride in the treatment of chronic nonbacterial prostatitis(CNP)with damp heat infusion type.Method:A total of 80 patients with damp heat infusion type CNP who visited the Urology Department of Fujian University of Traditional Chinese Medicine Affiliated People's Hospital from January 2021 to January 2024 were randomly divided into a combination treatment group(n=40)and a control group(n=40).Combination treatment group received oral Longqing Capsules combined with Tamsulosin Hydrochloride Sustained Release Capsules,while the control group received oral Tamsulosin Hydrochloride Sustained Release Capsules,the treatment period was one month.The clinical treatment effect of the patient,serum interleukin-6(IL-6),changes in white blood cells in expressed prostatic secretions(EPS),and the national institutes of health-chronic prostatitis symptom index(NIH-CPSI)score were observed between two groups.Result:The total effective rate of the combination treatment group was 90.00%,while the total effective rate of the control group was 67.50%,the total clinical effective rate of the combination treatment group was significantly higher than that of the control group,the difference was statistically significant(x2=6.050,P=0.014).After treatment,the combination treatment group and the control group were significant improved in pain or discomfort symptoms[(2.10±0.98)points vs(4.23±1.31)points],urinary symptoms[(3.23±0.73)points vs(4.73±0.91)points],quality of life[(3.73±0.99)points vs(4.68±1.07)points],and CPSI total score[(9.05±1.45)points vs(13.63±1.60)points],the differences were statistically significant(P<0.05).After treatment,the number of white blood cells in the prostate fluid of patients in the combination treatment group and the control group was significantly reduced compared to those before treatment(P<0.05),and the white blood cells in the combination treatment group was significantly reduced compared to the control group[(5.53±1.34)case/HP vs(7.73±1.60)case/HP],the difference was statistically significant(t=-6.665,P=0.001).After treatment,the levels of IL-6 in both groups were lower than those before treatment,the IL-6 in the combination treatment group was significantly decreased compared to that the control group[(6.12±1.43)pg/mL vs(7.98±0.99)pg/mL],the differences was statistically significant(P<0.05).During the clinical observation period,no significant adverse reactions were observed in all patients.Conclusion:The combination of Longqing Capsules and Tamsulosin Hydrochloride Sustained Release Capsules is effective in the treatment of CNP patients with damp heat infusion type,can improve their quality of life,and has high safety.
Chronic non bacterial prostatitisLongqing CapsulesDamp heat
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