Effects of Azithromycin on Efficacy,IgM Antibody Positive Rate,Lung Function and Immune Function in Children with Legionella Pneumonia
Objective:To explore the effect of Azithromycin on the positive rate of immunoglobulin M(IgM)antibody,lung function and immune function in children with Legionella pneumonia.Method:A total of 100 children with Legionella pneumonia admitted to Jiangxi Maternal and Child Health Hospital from October 2021 to December 2022 as the study subjects,they were divided into Azithromycin group and Erythromycin group by random number table method,with 50 cases in each group.Azithromycin was given to the Azithromycin group and Erythromycin was given to the Erythromycin group.The clinical efficacy,the positive rate of IgM antibody,pulmonary function indexes[respiratory rate(RR),peak expiratory flow(PEF),forced expiratory flow at 25%of vital capacity(FEF25),forced expiratory flow at 50%of vital capacity(FEF50),index of immune function[T lymphocyte subsets(CD3+,CD4+and CD8+)]were observed and compared between the two groups.Result:After medication,the total effective rate of Azithromycin group was significantly lower than that in the Erythromycin group,the difference was statistically significant(P<0.05).After one month of medication,the positive rate of IgM antibody in Azithromycin group was significantly lower than that of the Erythromycin group,the difference was statistically significant(P<0.05).After treatment,the FEF25,FEF50,CD3+and CD4+in the Azithromycin group were higher than those in the Erythromycin group,and the RR and CD8+were lower than those in the Erythromycin group,the differences were statistically significant(P<0.05),the PEF levels of the two groups were similar,the difference was not statistically significant(P>0.05).Conclusion:Azithromycin has a significant therapeutic effect on children with Legionella pneumonia,improving infection symptoms,expiratory function,and immune function,it can replace erythromycin as the preferred drug.
AzithromycinLegionella pneumoniaImmunoglobulin MLung functionImmune function
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