Effects of Letrozole Combined with Gonadotropin on Infertility Patients with PCOS
Objective:To investigate the effects of Letrozole combined with gonadotropin on endometrial thickness,luteinizing hormone(LH),ovulation and pregnancy in infertility patients with polycystic ovary syndrome(PCOS).Method:A total of 200 PCOS infertility patients admitted to the Fujian University of Traditional Chinese Medicine Affiliated Third People's Hospital from January to December 2022 were selected as the study objects,and they were divided into observation group and control group by random number table method,with 100 cases in each group.The control group was treated with gonadotropin alone,while the observation group was treated with Letrozole combined with gonadotropin.Endometrial thickness,LH,ovulation and pregnancy were compared between the two groups.Result:After treatment,endometrial thickness in both groups were higher than those before treatment,LH were lower than those before treatment,and endometrial thickness in observation group was higher than that in control group,LH was lower than that in control group,the differences were statistically significant(P<0.05).The follicle growth time of the observation group was shorter than that of the control group,and the number of ovulation and dominant follicles were higher than those of the control group,the differences were statistically significant(P<0.05).After 1 year of follow-up,the pregnancy rate of the observation group was higher than that of the control group,and the multiple pregnancy rate and abortion rate were lower than those of the control group,the differences were statisticaly significant(P<0.05).Conclusion:Letrozole combined with gonadotropin in the treatment of PCOS infertility can increase endometrial thickness,decrease LH level,promote ovulation and increase pregnancy rate.
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