Diagnostic Value of NT-proBNP,PCT,and ChE in Predicting the Prognosis of Patients with Heart Failure and Pulmonary Infection
Objective:To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide(NT-proBNP),procalcitonin(PCT)and cholinesterase(ChE)in prognosis of patients with heart failure and pulmonary infection.Method:A total of 100 patients with heart failure and pulmonary infection admitted to Qingyang Hospital of Traditional Chinese Medicine from March 2022 to October 2023 were selected as the observation group,and another 60 patients with simple heart failure admitted to our hospital during the same period were selected as the control group.After 6 months of follow-up,the observation group was divided into death group(n=29)and survival group(n=71)according to the prognosis.The levels of NT-proBNP,PCT and ChE in different groups were detected by magnetic particle Chemiluminescence.Receiver operator characteristic(ROC)cure was used to analyze the prognostic efficacy of each index in patients with heart failure and pulmonary infection.Result:The levels of NT-proBNP and PCT in observation group were significantly higher than those in control group,and ChE level was significantly lower than that in control group,the differences were statistically significant(P<0.05).The levels of NT-proBNP and PCT in death group were significantly higher than those in survival group,and ChE level was significantly lower than that in survival group,the differences were statistically significant(P<0.05).ROC curve results showed that the sensitivity of NT-proBNP,PCT and ChE to predict poor prognosis of patients with heart failure and pulmonary infection were 79.3%,79.3%and 93.1%,the specificity was 90.1%,84.5%and 53.5%,and the AUC was 0.902,0.873 and 0.713,respectively.While the sensitivity and specificity of the combined prediction of NT-proBNP,PCT and ChE increased to 93.1%and 93.0%,respectively,the AUC value reached 0.975,which were higher than the detection of NT-proBNP,PCT and ChE alone.Conclusion:NT-proBNP,PCT and ChE have significant diagnostic efficacy as biomarkers for the diagnosis of prognosis in patients with heart failure and pulmonary infection,especially,the combined detection of the three,which can provide important prognostic evaluation information for clinical practice.
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