黄连素与心肌纤维化相关性研究进展
Research Progress of Correlation between Berberine and Myocardial Fibrosis
刘志强 1孙经武1
作者信息
- 1. 滨州医学院附属医院心内科 山东 滨州 256603
- 折叠
摘要
近年来,心血管疾病(cardiovascular disease,CVD)的发生率正逐年上升.心肌纤维化是一种以成纤维细胞异常增殖、胶原过渡沉积及异常分布为特征的病理变化.在病理条件下(如高血压病、心肌病、冠心病),心肌功能受损,心肌细胞或细胞外部分基质、胶原纤维结缔组织均会发生一系列变化,该过程称为心肌重构,而心肌纤维化是心肌重构的基本病理过程,黄连素可改善心肌纤维化,现对心肌纤维化的致病机制及黄连素与心肌纤维化的研究进展进行系统综述.
Abstract
In recent years,the incidence of cardiovascular disease(CVD)is increasing year by year.Myocardial fibrosis is a pathological change characterized by abnormal proliferation of fibroblasts,excessive deposition and abnormal distribution of collagen.Under pathological conditions(such as hypertension,cardiomyopathy and coronary heart disease),myocardial function is damaged,and a series of changes occur in cardiomyocytes or extracellular matrix and collagen fiber connective tissue.This process is called myocardial remodeling,and myocardial fibrosis is the basic pathological process of myocardial remodeling.Berberine can improve myocardial fibrosis.This article reviews the pathogenesis of myocardial fibrosis and the research progress of berberine and myocardial fibrosis.
关键词
黄连素/心肌纤维化/病理性Key words
Berberine/Myocardial fibrosis/Pathological引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据