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肝癌术后辅助治疗的研究现状

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肝细胞癌(hepatocellular carcinoma,HCC),简称肝癌,是我国发病率及致死率分别位于第5 位和第 2 位的恶性肿瘤,肝癌的术后复发严重影响患者的预后,而肝癌术后进行辅助治疗是预防肝癌复发的重要手段.尽管国内外有研究证实了部分辅助治疗方案可延缓患者术后复发、延长患者生存期、改善患者预后等,国内也有专家共识对多种辅助治疗方案进行了推荐,包括抗病毒治疗、靶向治疗、免疫治疗、经肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)、肝动脉灌注化疗(hepatic arterial infusion chemotherapy,HAIC)、中医药治疗等,但肝癌术后的辅助治疗在肝癌综合治疗中的应用价值尚未完全明确,辅助治疗的受益人群也无法精准定位,因此肝癌术后辅助治疗的必要性仍存在争议.本文将对国内外进行的肝癌术后辅助治疗研究进行综述.
Research Status of Postoperative Adjuvant Therapy for Hepatocellular Carcinoma
Hepatocellular carcinoma(HCC),referred to as liver cancer,is the fifth and second malignant tumor in China in terms of incidence and mortality,respectively.Postoperative recurrence of liver cancer seriously affects the prognosis of patients,and postoperative adjuvant therapy is an important means to prevent the recurrence of liver cancer.Although domestic and foreign studies have confirmed that some adjuvant therapy protocols can delay postoperative recurrence,prolong survival time and improve prognosis of patients,there is also a consensus of experts in China to recommend a variety of adjuvant therapy protocols,including antiviral therapy,targeted therapy,immunotherapy,transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),traditional Chinese medicine treatment,etc.However,the application value of adjuvant therapy after liver cancer surgery in the comprehensive treatment of liver cancer is not completely clear,and the beneficiary population of adjuvant therapy can not be accurately positioned,so the necessity of adjuvant therapy after liver cancer surgery is still controversial.This article will review the research on postoperative adjuvant therapy for liver cancer at home and abroad.

Hepatocellular carcinomaAfter liver cancer surgeryRecurrenceAdjuvant therapy

宁金月、黄沾任、陈春雷

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广东医科大学附属第二医院肝胆外科 广东 湛江 524000

广东医科大学附属医院肝胆外科 广东 湛江 524000

肝细胞癌 肝癌术后 复发 辅助治疗

2024

中国医学创新
中国保健协会

中国医学创新

影响因子:1.706
ISSN:1674-4985
年,卷(期):2024.21(20)
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