Effect of Cefazolin Treatment after Rupture of Membranes on Serum Inflammatory Factors and Coagulation Function in Patients with Group B Streptococcal Infection in Late Pregnancy
Objective:To explore the effect of Cefazolin treatment after rupture of membranes on serum inflammatory factors and coagulation function in patients with group B streptococcal infection in late pregnancy.Method:A total of 100 patients with group B streptococcal infection in late pregnancy admitted to Yangjiang Maternal and Child Health Hospital from June 2021 to June 2023 were selected and divided into two groups by envelope method,with 50 cases in each group.Both groups were given symptomatic delivery intervention.After rupture of membranes,the patients in the control group were treated with Benzylpenicillin,and the study group was treated with Cefazolin.Serum inflammatory factors levels,coagulation function factors levels,postpartum related indicators,maternal adverse events and neonatal outcomes were recorded in the two groups.Result:Before treatment,there were no significant differences in leukocyte count,interleukin-6 and calcitonin levels between control group and study group(P>0.05).After treatment,all indexes of both groups were decreased,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in prothrombin time,international standardized ratio,activated partial thrombin time and thrombin time between the control group and the study group(P>0.05).After treatment,the prothrombin time and activated partial thrombin time in the study group were longer than those before treatment,and those in the study group were longer than those in the control group,the international standardized ratio was increased,and that in the study group was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in postpartum blood loss between the study group and the control group(P>0.05).The lochia time of study group was shorter than that of control group,and the lochia volume was less than that of the control group,the differences were statistically significant(P<0.05).There were no significant differences in the incidences of transit cesarean section,fever during delivery,postpartum fever,chorionic amnionitis,amniotic fluid contamination and lateral episiotomy between the study group and the control group(P>0.05).The incidence of puerperal infection in the study group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in the incidences of neonatal pneumonia,neonatal septicemia,pathological jaundice,asphyxia and meningitis between the two groups(P>0.05).Conclusion:In patients with group B streptococcal infection in late pregnancy,treatment with cephalosporin antibiotic of Cefazolin after rupture of membranes can significantly reduce the levels of serum inflammatory factors in patients,improve coagulation function,reduce the occurrence of amniotic fluid contamination,and do not have adverse effects on newborn health.
AntibioticsLate pregnancyGroup B streptococcus infectionCoagulation function
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维普
