Effect of Percutaneous Atrial Septal Defect Closure on Myocardial Injury Markers and Long-term Prognosis in Children with Atrial Septal Defect
Objective:To investigate the effect of percutaneous atrial septal defect(ASD)occlusion on myocardial injury markers and long-term prognosis in children with ASD.Method:Using a retrospective study,80 children with ASD admitted to Jiangxi Provincial Children's Hospital from January 2020 to December 2021 were divided into group A(n=38)and group B(n=42)according to different treatment methods.Children in group A were treated with traditional extracorporeal circulation ASD repair and children in group B were treated with percutaneous ASD occlusion.Operation related indexes,inflammatory factors[hypersensitivity C reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],myocardial injury markers[creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI)]and right ventricular function were compared between the two groups,and the incidence of postoperative complications were measured.Result:The operation time and postoperative hospitalization time of group B were shorter than those of group A,and the blood transfusion rate was lower than that of group A(P<0.05).Before operation,there were no significant differences in serum hs-CRP,IL-6 and TNF-α levels between the two groups(P>0.05).1 day after operation,the levels of above inflammatory factors were increased in both groups,but those in group B were lower than those in group A(P<0.05).Before operation,there were no significant differences in serum CK-MB and cTnI levels between the two groups(P>0.05).1 day after operation,the above serum indexes in both groups were increased,but those in group B were lower than those in group A(P<0.05).Before operation,there were no significant differences in right ventricular end-diastolic area and right ventricular end-systolic area between two groups(P>0.05).6 months after operation,the above indexes of both groups were decreased,and those in group B were smaller than those in group A(P<0.05).There was no significant difference in complication rate between the two groups(x2=0.459,P>0.05).Conclusion:The application of percutaneous ASD closure in children with ASD is effective,which can reduce inflammatory reaction and myocardial injury,improve right ventricular function,and has good safety.
万方数据
维普
