Effect of Combination of Ergometrine Maleate and Carboprost Methylate Suppository in Prevention and Treatment of Postpartum Hemorrhage Caused by Uterine Atony
Objective:To investigate the clinical effect of Ergometrine Maleate combined with Carboprost Methylate Suppository in the prevention and treatment of postpartum hemorrhage caused by uterine atony.Method:A total of 70 puerpera with uterine atony were selected as the study objects,all of whom were treated in the Obstetrics and Gynecology Department of Ji'an First People's Hospital from March 2020 to September 2023,and they were divided into two groups by random number table method,with 35 cases in each group.The control group was treated with Carboprost Methylate Suppository,and the observation group was treated with Ergometrine Maleate combined with Carboprost Methylate Suppository.The clinical efficacy,postpartum blood loss,coagulation function and inflammatory factors were compared between the two groups.Result:The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Postpartum blood loss in the observation group was less than that in the control group,the duration of lochia was shorter than that of control group,the differences were statistically significant(P<0.05).After treatment,fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)were higher than those of control group;the levels of tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and C reactive protein(CRP)were lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:Ergometrine Maleate combined with Carboprost Methylate Suppository therapy can significantly reduce puerpera with uterine atony postpartum hemorrhage,shorten the duration of lochia,effectively improve postpartum coagulation function and reduce the levels of inflammatory factors,and is safe and reliable.
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