Application of Eucalyptol,Limonene and Pinene Enteric Soft Capsules and Budesonide Aerosol in the Treatment of Chronic Sinusitis with Nasal Polyps after Nasal Endoscopy
Objective:To explore the therapeutic effect of Eucalyptol,Limonene and Pinene Enteric Soft Capsules and Budesonide Aerosol after nasal endoscopy in patients with chronic sinusitis with nasal polyps(CRSwNP).Method:A total of 80 CRSwNP patients from January 2020 to December 2023 who underwent nasal endoscopy in Huangshi Fifth Hospital were selected,and they were randomly divided into the study group(40 cases)and the control group(40 cases).The control group was treated with Budesonide Aerosol,while the study group was treated with Eucalyptol,Limonene and Pinene Enteric Soft Capsules combined with Budesonide Aerosol.The clinical efficacy,symptom disappearance time,nasal mucosal function,inflammatory factors and adverse reactions in both groups were compared.Result:In the total effective rate of treatment,95.00%(38/40)in the study group was higher than 77.50%(31/40)in the control group(P<0.05);the disappearance time of symptoms(nasal congestion and runny nose,nasal mucosal edema,abnormal smell and vesicles)in the study group were earlier than those in the control group(P<0.05).After treatment,the mocociliary clearance(MCC)in both groups were increased,and the saccharin clearance time(SCT)were shortened(P<0.05),in comparision of the control group,the MCC of the study group was higher,and the SCT was shorter(P<0.05).After treatment,the interleukin-1β(IL-1β),interleukin-6(IL-6)and C reactive protein(CRP)levels in both groups were decreased(P<0.05),and in comparision of the control group,those in the study group were lower(P<0.05).In the incidence of adverse reactions,the study group[10.00%(4/40)]and the control group[5.00%(2/40)]was no statistically significant difference(P>0.05).Conclusion:The use of Eucalyptol,Limonene and Pinene Enteric Soft Capsules and Budesonide Aerosol after nasal endoscopy in CRSwNP patients can improve clinical efficacy,shorten symptom disappearance time,improve nasal mucosal function,regulate inflammatory factor levels,and have high safety.
Chronic sinusitisNasal polypsNasal endoscopyEucalyptol,Limonene and Pinene Enteric Soft CapsulesBudesonide Aerosol
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