Application Value of Combined Detection of Peripheral Blood Prealbumin,hs-CRP,SAA and IL-6 in Children with Upper Respiratory Tract Infection
Objective:To analyze the application value of combined detection of peripheral blood prealbumin(PAB),hypersensitive C reactive protein(hs-CRP),serum amyloid A(SAA)and leukocyte-6(IL-6)in children with upper respiratory tract infection.Method:A total of 100 children with upper respiratory tract infection treated in the Second Affiliated Hospital of Gannan Medical University from March to September 2023 were selected as the study objects.Peripheral blood PAB,hs-CRP,SAA and IL-6 were detected in all subjects,and the children were divided into severe infection group,moderate infection group and mild infection group according to pediatric clinical illness score(PCIS).The levels of PAB,hs-CRP,SAA and IL-6 in peripheral blood of all groups were compared,and the diagnostic value of PAB,hs-CRP,SAA and IL-6 in children with severe upper respiratory tract infection were analyzed.Result:The levels of hs-CRP,SAA and IL-6 in peripheral blood of severe infection group were higher than those of mild infection group and moderate infection group,PAB was lower than that in mild infection group and moderate infection group,SAA and IL-6 in moderate infection group were higher than those in mild infection group(P<0.05).Pearson or Spearman correlation analysis showed that in children with upper respiratory tract infection,PAB was significant negatively correlated with PCIS score(P<0.05),while hs-CRP,SAA and IL-6 were significant positively correlated with PCIS score(P<0.05).ROC curve showed that the areas under the curve of PAB,hs-CRP,SAA,IL-6 and their combined diagnosis of severe upper respiratory tract infection in children were 0.654,0.740,0.928,0.783 and 0.962,respectively.Conclusion:Children with upper respiratory tract infections have decreased PAB levels and increased hs-CRP,SAA,and IL-6 levels,which have high diagnostic value for severe upper respiratory tract infections.
Upper respiratory tract infectionPrealbuminHypersensitive C reactive proteinSerum amyloid AInterleukin-6
万方数据
维普
