Clinical Pathological Significance of Expression Deficiency of Mismatch Repair Proteins in Early Low-grade Endometrioid Carcinoma
Objective:To explore the clinical pathological significance of expression deficiency of mismatch repair proteins in early low-grade endometrioid carcinoma,in order to provide reference for the diagnosis and formulation of treatment measures of early low-grade endometrioid carcinoma.Method:A total of 40 patients with early low-grade endometrioid carcinoma admitted to Ganzhou Women and Children's Health Care Hospital from February 2021 to February 2024 were selected as the observation group,and 40 patients with high-grade endometrioid carcinoma admitted during the same period were selected as the control group.Immunohistochemical stain was used to detect the expression of four mismatch repair proteins[post meiotic segregation 2(PMS2),MutL homologue 1(MLH1),MutS homologue 2(MSH2)and MutS homologue 6(MSH6)]in all the pathological tissues.The expression deficiency of mismatch repair proteins in the two groups and in patients with different ages,body mass index(BMI),federation international of gynecology and obstetric(FIGO)stages and histological grades in the observation group were compared.Result:The expression deficiency rates of PMS2,MLH1 and MSH2 in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the expression deficiency rate of MSH6 between the two groups(P>0.05).There were significant differences in the expression deficiency rates of PMS2,MLH1,MSH2 and MSH6 among patients with different ages,FIGO stages and histological grades(P<0.05).There were no significant differences in the expression deficiency rates of PMS2,MLH1,MSH2 and MSH6 among patients with different BMI in the observation group(P>0.05).Conclusion:The expression deficiency rates of mismatch repair proteins in early low-grade endometrioid carcinoma are significantly lower than those in high-grade endometrioid carcinoma,and there are significant differences in the expression deficiency rates of mismatch repair proteins in low-grade endometrioid carcinoma patients with different ages,FIGO stages and histological grades.
Early stageSporadicLow-grade endometrioid carcinomaMismatch repair proteinsPathological significance
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维普
